Asymptomatic elevation of the hyperchromic red blood cell subpopulation is associated with decreased red cell deformability

Analyzing red blood cell-deformability distributions.

BACKGROUND Red blood cells (RBCs) must deform to pass the smallest capillaries of the microcirculation. Available techniques for measuring RBC deformability often provide an indication of the mean deformability. The latter may be decreased either by a slight overall deformability reduction or by the presence of a small fraction of rigid cells. A distinction between these two cases can be made w...

The Effects of Nitric Oxide on Red Blood Cell Deformability

Effects of nitric oxide on red blood cell deformability.

In addition to its known action on vascular smooth muscle, nitric oxide (NO) has been suggested to have cardiovascular effects via regulation of red blood cell (RBC) deformability. The present study was designed to further explore this possibility. Human RBCs in autologous plasma were incubated for 1 h with NO synthase (NOS) inhibitors [N(omega)-nitro-l-arginine methyl ester (l-NAME) and S-meth...

Association of reduced red blood cell deformability and diabetic nephropathy.

BACKGROUND Impaired red blood cell deformability may play a key role in the pathogenesis of chronic vascular complications of diabetes mellitus and progression of renal failure. The present study was conducted to test whether impaired red blood cell deformability is indeed associated with development of diabetic nephropathy. METHODS We studied 57 adult type 2 diabetic patients divided into th...

Species-specific effects of anticoagulants on red blood cell deformability.

N. Nemeth a,∗, O.K. Baskurt b, H.J. Meiselman c and I. Miko a a Medical and Health Science Center, Department of Operative Techniques and Surgical Research, Institute of Surgery, University of Debrecen, Debrecen, Hungary b Department of Physiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey c Department of Physiology and Biophysics, University of Southern California, Keck School o...